5FHM

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor 2,Glutamate receptor 2	polymer	264	29278.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Ionotropic glutamate receptor A2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Ionotropic glutamate receptor A2
2	C, D, E, P, Q... (A, B)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	F (A)	(2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid	non-polymer		359.3	1	Chemie (5XP)
4	G, S (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	H, T, U, V (A, B)	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
6	I, J, K, L, M... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
7	N, O (A, B)	LITHIUM ION	non-polymer		6.9	2	Chemie (LI)
8	Y, Z (A, B)	water	water		18.0	686	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58557.5
Non-Polymers*	Number of molecules	22
	Total formula weight	1804.4
All*	Total formula weight	60361.9

*Water molecules are not included.