5FHM
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | MET107 |
| A | SER108 |
| A | HOH438 |
| A | HOH549 |
| A | HOH611 |
| B | SER217 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | HOH401 |
| A | HOH402 |
| A | HOH406 |
| A | HOH468 |
| A | HOH633 |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ARG64 |
| A | LYS69 |
| A | HOH639 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue 5XP A 304 |
| Chain | Residue |
| A | GLU13 |
| A | SER14 |
| A | TYR16 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | LEU192 |
| A | GLU193 |
| A | THR195 |
| A | MET196 |
| A | EDO307 |
| A | HOH418 |
| A | HOH453 |
| A | HOH574 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ASP248 |
| A | ASN252 |
| B | ASN214 |
| B | ASP216 |
| B | SER217 |
| B | HOH576 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 306 |
| Chain | Residue |
| A | ALA153 |
| A | HOH506 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | GLU13 |
| A | SER14 |
| A | 5XP304 |
| A | HOH574 |
| A | HOH594 |
| A | HOH706 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | HOH403 |
| A | HOH637 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 309 |
| Chain | Residue |
| A | LYS144 |
| A | ARG163 |
| A | PHE170 |
| A | HOH600 |
| A | HOH606 |
| B | GLU24 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 310 |
| Chain | Residue |
| A | HIS46 |
| A | LYS240 |
| A | GLN244 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 311 |
| Chain | Residue |
| A | LYS116 |
| A | LYS185 |
| A | HOH421 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue LI A 312 |
| Chain | Residue |
| A | ASN242 |
| A | HOH467 |
| A | HOH487 |
| B | SER217 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue LI B 301 |
| Chain | Residue |
| B | GLU97 |
| B | ILE100 |
| B | ASP101 |
| B | HOH456 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | THR91 |
| B | ARG96 |
| B | SER142 |
| B | HOH401 |
| B | HOH446 |
| B | HOH610 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| A | HIS23 |
| B | LYS144 |
| B | ARG148 |
| B | ARG163 |
| B | HOH410 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | GLU13 |
| B | SER14 |
| B | HOH429 |
| B | HOH437 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | TYR80 |
| A | HOH470 |
| B | LYS116 |
| B | LYS185 |
| B | HOH413 |
| B | HOH575 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 306 |
| Chain | Residue |
| B | ARG172 |
| B | LYS240 |
| B | GLN244 |
| B | HIS46 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 307 |
| Chain | Residue |
| B | LYS151 |
| B | ILE152 |
| B | ALA153 |
| B | HOH616 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 308 |
| Chain | Residue |
| A | HOH443 |
| B | LYS20 |
| B | ASN22 |
| B | HOH426 |
| B | HOH441 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 309 |
| Chain | Residue |
| B | LYS60 |
| B | TYR61 |
| B | GLY62 |
| B | ARG96 |
| B | HOH568 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 310 |
| Chain | Residue |
| A | ASN214 |
| A | ASP216 |
| A | SER217 |
| B | ASP248 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
