5FFG
Crystal structure of integrin alpha V beta 6 head
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-V | polymer | 601 | 65982.9 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) | Homo sapiens (Human) | Vitronectin receptor subunit alpha |
| 2 | B (B) | Integrin beta-6 | polymer | 257 | 28851.7 | 1 | UniProt (P18564) Pfam (PF00362) | Homo sapiens (Human) | |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, F (D, F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 6 | G (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 7 | H, I, J, K, P... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 8 | L, R (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 9 | M (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 10 | N (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 11 | O, S (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 12 | T, U (A, B) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 1 - 598 (UniProt: P06756)
B: 111 - 361 (UniProt: P18564)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | insertion |
| Cys 401 | Met 430 | conflict |
| Thr 597 | Cys 626 | conflict |
| Gly 599 | - | expression tag |
| Leu 600 | - | expression tag |
| Glu 601 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 270 | Ile 287 | conflict |
| His 362 | - | expression tag |
| His 363 | - | expression tag |
| His 364 | - | expression tag |
| His 365 | - | expression tag |
| His 366 | - | expression tag |
| His 367 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 94834.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 4067.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1186.4 | |
| All* | Total formula weight | 100088.7 |
