5FDP
Structure of DDR1 receptor tyrosine kinase in complex with D2099 inhibitor at 2.25 Angstroms resolution.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epithelial discoidin domain-containing receptor 1 | polymer | 337 | 38282.8 | 1 | UniProt (Q08345) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial discoidin domain receptor 1,CD167 antigen-like family member A,Cell adhesion kinase,Discoidin receptor tyrosine kinase,HGK2,Mammary carcinoma kinase 10,MCK-10,Protein-tyrosine kinase 3A,Protein-tyrosine kinase RTK-6,TRK E,Tyrosine kinase DDR,Tyrosine-protein kinase CAK |
2 | A | (4~{S})-4-methyl-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinoline-7-carboxamide | non-polymer | 524.6 | 1 | Chemie (5WR) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
A: 601 - 913 (UniProt: Q08345)
PDB | External Database | Details |
---|---|---|
Met 577 | - | initiating methionine |
Gly 578 | - | expression tag |
His 579 | - | expression tag |
His 580 | - | expression tag |
His 581 | - | expression tag |
His 582 | - | expression tag |
His 583 | - | expression tag |
His 584 | - | expression tag |
Ser 585 | - | expression tag |
Ser 586 | - | expression tag |
Gly 587 | - | expression tag |
Val 588 | - | expression tag |
Asp 589 | - | expression tag |
Leu 590 | - | expression tag |
Gly 591 | - | expression tag |
Thr 592 | - | expression tag |
Glu 593 | - | expression tag |
Asn 594 | - | expression tag |
Leu 595 | - | expression tag |
Tyr 596 | - | expression tag |
Phe 597 | - | expression tag |
Gln 598 | - | expression tag |
Ser 599 | - | expression tag |
Met 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38282.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 941.0 | |
All* | Total formula weight | 39223.8 |