Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 5WR A 1001 |
| Chain | Residue |
| A | ALA653 |
| A | TYR703 |
| A | MET704 |
| A | PHE762 |
| A | HIS764 |
| A | ALA783 |
| A | ASP784 |
| A | HOH1190 |
| A | LYS655 |
| A | GLU672 |
| A | MET676 |
| A | LEU679 |
| A | ILE685 |
| A | MET699 |
| A | THR701 |
| A | ASP702 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PEG A 1002 |
| Chain | Residue |
| A | ASN710 |
| A | ALA768 |
| A | THR769 |
| A | ARG770 |
| A | ASP795 |
| A | TRP809 |
| A | GLU835 |
| A | ALA842 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1003 |
| Chain | Residue |
| A | MET817 |
| A | GLY818 |
| A | ARG841 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1004 |
| Chain | Residue |
| A | HIS745 |
| A | ALA748 |
| A | HIS902 |
| A | HOH1110 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1005 |
| Chain | Residue |
| A | ARG890 |
| A | SER892 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1006 |
| Chain | Residue |
| A | TRP827 |
| A | PHE845 |
| A | TYR869 |
| A | LEU870 |
| A | TRP888 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1007 |
| Chain | Residue |
| A | ALA758 |
| A | THR759 |
| A | PRO897 |
| A | PHE898 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE762-VAL774 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR |
| Chain | Residue | Details |
| A | ASN790-ARG798 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16337946","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"24509848","evidenceCode":"ECO:0000269"}]} |
