5FBW
PI4KB in complex with Rab11 and the MI369 Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta | polymer | 572 | 65264.8 | 1 | UniProt (Q9UBF8) Pfam (PF21245) Pfam (PF00454) | Homo sapiens (Human) | PtdIns 4-kinase beta,NPIK,PI4K92,PtdIns 4-kinase beta,NPIK,PI4K92 |
| 2 | B (B) | Ras-related protein Rab-11A | polymer | 221 | 24813.0 | 1 | UniProt (P62491) Pfam (PF00071) | Homo sapiens (Human) | Rab-11,YL8 |
| 3 | C (A) | ~{N}-[2-[[6-chloranyl-3-[4-methoxy-3-[[(2~{R})-1-oxidanylbutan-2-yl]sulfamoyl]phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide | non-polymer | 525.0 | 1 | Chemie (5W8) | |||
| 4 | D (B) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) |
Sequence modifications
A: 128 - 522 (UniProt: Q9UBF8)
A: 523 - 799 (UniProt: Q9UBF8)
B: 1 - 216 (UniProt: P62491)
A: 523 - 799 (UniProt: Q9UBF8)
B: 1 - 216 (UniProt: P62491)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 70 | Gln 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90077.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1064.3 | |
| All* | Total formula weight | 91142.0 |
