5FBQ

PI4KB in complex with Rab11 and the MI358 Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta	polymer	572	65264.8	1	UniProt (Q9UBF8) Pfam (PF21245) Pfam (PF00454) In PDB	Homo sapiens (Human)	PtdIns 4-kinase beta,NPIK,PI4K92,PI4KB,PtdIns 4-kinase beta,NPIK,PI4K92,PI4KB
2	B	Ras-related protein Rab-11A	polymer	221	24828.0	1	UniProt (P62491) Pfam (PF00071) In PDB	Homo sapiens (Human)	Rab-11,YL8
3	A	~{N}-[2-[[6-chloranyl-3-[3-[4-(hydroxymethyl)piperidin-1-yl]sulfonyl-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide	non-polymer		551.1	1	Chemie (5W6)
4	B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)

Sequence modifications

A: 128 - 522 (UniProt: Q9UBF8)
A: 523 - 799 (UniProt: Q9UBF8)
B: 1 - 216 (UniProt: P62491)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90092.7
Non-Polymers*	Number of molecules	2
	Total formula weight	994.3
All*	Total formula weight	91087.0

*Water molecules are not included.