5FA5
Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein arginine N-methyltransferase 5 | polymer | 650 | 74281.3 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B (B) | Methylosome protein 50 | polymer | 367 | 39857.5 | 1 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | C (C) | Histone H4 | polymer | 20 | 2001.4 | 1 | UniProt (P62805) | Homo sapiens | |
| 4 | D (A) | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) PubChem (149) PubChem (25322898) PubChem (40467850) PubChem (44264468) PubChem (46874793) PubChem (51397471) PubChem (57104771) PubChem (58108938) PubChem (58682801) PubChem (439176) PubChem (59099797) PubChem (51397472) PubChem (688097) PubChem (99302) PubChem (453683) PubChem (91614589) PubChem (98100246) PubChem (6541356) PubChem (124300729) PubChem (124300795) PubChem (13101165) PubChem (13101166) PubChem (134694842) PubChem (138107656) PubChem (164077596) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A: 1 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
| PDB | External Database | Details |
|---|---|---|
| Met -12 | - | initiating methionine |
| Asp -11 | - | expression tag |
| Tyr -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Thr 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -24 | - | initiating methionine |
| Ser -23 | - | expression tag |
| Tyr -22 | - | expression tag |
| Tyr -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 116140.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 297.3 | |
| All* | Total formula weight | 116437.4 |
