5F9Z

Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Aminoacyl-tRNA synthetase	polymer	511	59312.0	2	UniProt (Q7YZ69) In PDB	Cryptosporidium parvum
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	A, B	7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one	non-polymer		414.7	2	Chemie (HFG)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7		water	water		18.0	436	Chemie (HOH)

Sequence modifications

A, B: 186 - 688 (UniProt: Q7YZ69)

PDB	External Database	Details
Met 178	-	expression tag
Ala 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	118624.0
Non-Polymers*	Number of molecules	9
	Total formula weight	2113.3
All*	Total formula weight	120737.3

*Water molecules are not included.