5F9Z
Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 700 |
| Chain | Residue |
| A | ANP701 |
| A | HOH804 |
| A | HOH833 |
| A | HOH894 |
| A | HOH897 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue ANP A 701 |
| Chain | Residue |
| A | ARG342 |
| A | THR343 |
| A | PHE346 |
| A | GLN416 |
| A | THR419 |
| A | THR453 |
| A | ARG455 |
| A | MG700 |
| A | HFG702 |
| A | HOH833 |
| A | HOH835 |
| A | HOH894 |
| A | HOH897 |
| A | HOH901 |
| A | ARG331 |
| A | GLU333 |
| A | PHE340 |
| A | ILE341 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue HFG A 702 |
| Chain | Residue |
| A | GLU274 |
| A | GLY275 |
| A | PHE276 |
| A | GLU279 |
| A | VAL280 |
| A | PRO299 |
| A | THR300 |
| A | GLU302 |
| A | ARG331 |
| A | TRP348 |
| A | PHE395 |
| A | THR419 |
| A | HIS421 |
| A | TRP450 |
| A | GLY451 |
| A | ANP701 |
| A | HOH804 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 703 |
| Chain | Residue |
| A | CYS621 |
| A | CYS626 |
| A | CYS671 |
| A | CYS674 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 701 |
| Chain | Residue |
| B | ANP702 |
| B | HOH802 |
| B | HOH822 |
| B | HOH834 |
| B | HOH841 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue ANP B 702 |
| Chain | Residue |
| B | ARG331 |
| B | GLU333 |
| B | PHE340 |
| B | ILE341 |
| B | ARG342 |
| B | THR343 |
| B | PHE346 |
| B | GLN416 |
| B | THR453 |
| B | ARG455 |
| B | MG701 |
| B | HFG703 |
| B | HOH801 |
| B | HOH822 |
| B | HOH825 |
| B | HOH834 |
| B | HOH841 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue HFG B 703 |
| Chain | Residue |
| B | PHE276 |
| B | GLU279 |
| B | VAL280 |
| B | PRO299 |
| B | THR300 |
| B | GLU302 |
| B | ARG331 |
| B | TRP348 |
| B | PHE395 |
| B | THR419 |
| B | HIS421 |
| B | TRP450 |
| B | GLY451 |
| B | ANP702 |
| B | HOH802 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 704 |
| Chain | Residue |
| B | CYS621 |
| B | CYS626 |
| B | CYS671 |
| B | CYS674 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 705 |
| Chain | Residue |
| B | GLN253 |
| B | PRO320 |
| B | HOH891 |
