5F8X
The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3
Replaces: 4ZJ6Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasma kallikrein | polymer | 239 | 26913.6 | 1 | UniProt (P03952) Pfam (PF00089) | Homo sapiens (Human) | Fletcher factor,Kininogenin,Plasma prekallikrein,PKK |
| 2 | B (B) | CYS-PRO-ALA-ARG-PHE-M70-ALA-LEU-TRP-CYS | polymer | 10 | 1138.4 | 1 | synthetic construct | ||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | K (B) | piperidine-1-carboximidamide | non-polymer | 127.2 | 1 | Chemie (MRZ) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence modifications
A: 16 - 246 (UniProt: P03952)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28052.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 895.7 | |
| All* | Total formula weight | 28947.7 |
