5F8P
A Novel Inhibitor of the Obesity-Related Protein FTO
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Alpha-ketoglutarate-dependent dioxygenase FTO | polymer | 476 | 54821.8 | 1 | UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB | Homo sapiens (Human) | Fat mass and obesity-associated protein |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 4-chloranyl-6-[(2~{S})-6-chloranyl-2,4,4-trimethyl-7-oxidanyl-3~{H}-chromen-2-yl]benzene-1,3-diol | non-polymer | 369.2 | 1 | Chemie (FIJ) | |||
| 4 | A | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 5 | A | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 6 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 32 - 502 (UniProt: Q9C0B1)
| PDB | External Database | Details |
|---|---|---|
| Leu 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
| Met 31 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54821.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 667.2 | |
| All* | Total formula weight | 55489.1 |
