5F6J
Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (G, E) | ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C | polymer | 352 | 39031.2 | 2 | UniProt (R4GRV3) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | C, E (A, F) | DH427 Antibody Light Chain | polymer | 216 | 22858.2 | 2 | Macaca mulatta | ||
| 3 | D, F (B, H) | DH427 Antibody Heavy Chain | polymer | 228 | 24375.2 | 2 | Macaca mulatta |
Sequence modifications
G, E: 44 - 492 (UniProt: R4GRV3)
| PDB | External Database | Details |
|---|---|---|
| Lys 458 | Gly 321 | engineered mutation |
| - | Gly 322 | deletion |
| - | Asn 323 | deletion |
| - | Asp 324 | deletion |
| Ser 463 | Asn 326 | engineered mutation |
| Asn 464 | Asp 327 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 172529.2 | |
| All* | Total formula weight | 172529.2 |
