5EYC
Crystal structure of c-Met in complex with naphthyridinone inhibitor 5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 309 | 35215.7 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | A | 6-[(1~{R})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one | non-polymer | 390.4 | 1 | Chemie (5SZ) | |||
| 3 | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A: 1048 - 1351 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
| His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35215.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.4 | |
| All* | Total formula weight | 35606.1 |
