5EX5

Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with 7-deaza-ADP and inorganic phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	78 kDa glucose-regulated protein	polymer	400	44356.1	2	UniProt (P11021) Pfam (PF00012) In PDB	Homo sapiens (Human)	GRP-78, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A, B	7-deazaadenosine-5'-diphosphate	non-polymer		426.2	2	Chemie (7DD)
5		water	water		18.0	500	Chemie (HOH)

Sequence modifications

A, B: 26 - 407 (UniProt: P11021)

PDB	External Database	Details
Met 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
Ser 15	-	expression tag
Ser 16	-	expression tag
Gly 17	-	expression tag
Arg 18	-	expression tag
Glu 19	-	expression tag
Asn 20	-	expression tag
Leu 21	-	expression tag
Tyr 22	-	expression tag
Phe 23	-	expression tag
Gln 24	-	expression tag
Gly 25	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88712.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1091.0
All*	Total formula weight	89803.2

*Water molecules are not included.