5EX3
Crystal structure of human SMYD3 in complex with a VEGFR1 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SMYD3 | polymer | 436 | 49963.0 | 1 | UniProt (Q9H7B4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (Human) | SET and MYND domain-containing protein 3,Zinc finger MYND domain-containing protein 1 |
| 2 | B (D) | VEGFR1 peptide | polymer | 9 | 1001.3 | 1 | UniProt (by SIFTS) (P17948) | Homo sapiens | |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 5 | G, H, I, J (A) | ACETIC ACID | non-polymer | 60.1 | 4 | Chemie (ACY) | |||
| 6 | K, L (A, D) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 1 - 428 (UniProt: Q9H7B4)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Asn 13 | Lys 13 | engineered mutation |
| Arg 140 | Lys 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50964.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 820.8 | |
| All* | Total formula weight | 51785.1 |
