5EX0
Crystal structure of human SMYD3 in complex with a MAP3K2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SMYD3 | polymer | 431 | 49541.5 | 1 | UniProt (Q9H7B4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (Human) | SET and MYND domain-containing protein 3,Zinc finger MYND domain-containing protein 1 |
| 2 | B (D) | MAP3K2 peptide | polymer | 10 | 1085.2 | 1 | UniProt (by SIFTS) (Q9Y2U5) | Homo sapiens | |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 5 | G, H (A) | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
| 6 | I, J (A, D) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 1 - 428 (UniProt: Q9H7B4)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Asn 13 | Lys 13 | engineered mutation |
| Arg 140 | Lys 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50626.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 700.7 | |
| All* | Total formula weight | 51327.4 |
