5EUD
S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Putative sphingosine-1-phosphate lyase | polymer | 514 | 55741.0 | 2 | UniProt (Q67PY4) Pfam (PF00282) In PDB | Symbiobacterium thermophilum (strain T / IAM 14863) | |
2 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
3 | A | ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-[4-(3-oxidanylprop-1-ynyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide | non-polymer | 447.5 | 2 | Chemie (5S6) | |||
4 | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 507 (UniProt: Q67PY4)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Pro 1 | - | expression tag |
Phe 249 | Tyr 249 | engineered mutation |
Ile 344 | Leu 344 | engineered mutation |
Ala 346 | Phe 346 | engineered mutation |
Ser 497 | Leu 497 | engineered mutation |
His 508 | - | expression tag |
His 509 | - | expression tag |
His 510 | - | expression tag |
His 511 | - | expression tag |
His 512 | - | expression tag |
His 513 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 111482.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1085.0 | |
All* | Total formula weight | 112567.1 |