5EUD
S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004058 | molecular_function | aromatic-L-amino-acid decarboxylase activity |
| A | 0008117 | molecular_function | sphinganine-1-phosphate aldolase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030149 | biological_process | sphingolipid catabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0004058 | molecular_function | aromatic-L-amino-acid decarboxylase activity |
| B | 0008117 | molecular_function | sphinganine-1-phosphate aldolase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030149 | biological_process | sphingolipid catabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 601 |
| Chain | Residue |
| A | ALA103 |
| A | TYR105 |
| A | LLP311 |
| A | HOH705 |
| A | HOH732 |
| A | HOH775 |
| B | ASN126 |
| B | HIS129 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue 5S6 A 602 |
| Chain | Residue |
| A | PHE249 |
| A | LLP311 |
| A | VAL496 |
| A | PHE500 |
| B | PRO127 |
| B | LEU128 |
| B | PRO130 |
| B | TRP340 |
| B | GLY342 |
| B | ILE344 |
| B | TYR345 |
| B | ALA346 |
| B | HOH714 |
| A | HIS201 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue 5S6 A 603 |
| Chain | Residue |
| A | LEU128 |
| A | PRO130 |
| A | TRP340 |
| A | GLY342 |
| A | ILE344 |
| A | TYR345 |
| A | ALA346 |
| A | HOH712 |
| A | HOH747 |
| B | HIS201 |
| B | PHE249 |
| B | LLP311 |
| B | SER497 |
| B | PHE500 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 B 601 |
| Chain | Residue |
| A | ASN126 |
| A | LEU128 |
| A | HIS129 |
| A | HOH712 |
| A | HOH745 |
| B | ALA103 |
| B | TYR105 |
| B | LLP311 |
| B | HOH703 |
| B | HOH738 |
| B | HOH741 |
| B | HOH800 |
