5ETY
Crystal Structure of human Tankyrase-1 bound to K-756
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Tankyrase-1 | polymer | 257 | 29289.0 | 4 | UniProt (O95271) Pfam (PF00644) In PDB | Homo sapiens (Human) | TANK1,ADP-ribosyltransferase diphtheria toxin-like 5,ARTD5,Poly [ADP-ribose] polymerase 5A,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one | non-polymer | 433.5 | 4 | Chemie (K56) | |||
4 | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1091 - 1324 (UniProt: O95271)
PDB | External Database | Details |
---|---|---|
Met 1068 | - | initiating methionine |
His 1069 | - | expression tag |
His 1070 | - | expression tag |
His 1071 | - | expression tag |
His 1072 | - | expression tag |
His 1073 | - | expression tag |
His 1074 | - | expression tag |
Ser 1075 | - | expression tag |
Ser 1076 | - | expression tag |
Gly 1077 | - | expression tag |
Val 1078 | - | expression tag |
Asp 1079 | - | expression tag |
Leu 1080 | - | expression tag |
Gly 1081 | - | expression tag |
Thr 1082 | - | expression tag |
Glu 1083 | - | expression tag |
Asn 1084 | - | expression tag |
Leu 1085 | - | expression tag |
Tyr 1086 | - | expression tag |
Phe 1087 | - | expression tag |
Gln 1088 | - | expression tag |
Ser 1089 | - | expression tag |
Met 1090 | - | expression tag |
Ile 1266 | Met 1266 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 117155.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1995.6 | |
All* | Total formula weight | 119151.5 |