5ESZ
Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, A | CH04 Heavy Chain | polymer | 244 | 26205.2 | 2 | UniProt (A0A087WYE1) In PDB | Homo sapiens | |
2 | L, B | CH04 Light Chain | polymer | 215 | 23754.4 | 2 | UniProt (P01834) Pfam (PF07654) In PDB | Homo sapiens | |
3 | C, G | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160 | polymer | 222 | 24333.8 | 2 | UniProt (P44815) UniProt (Q4QX31) Pfam (PF02542) In PDB | Haemophilus influenzae | MECPS,Endogenous retrovirus group K member 113 Env polyprotein,Endogenous retrovirus group K member 13-1 Env polyprotein,Endogenous retrovirus group K member 18 Env polyprotein,Endogenous retrovirus group K member 19 Env polyprotein,Endogenous retrovirus group K member 21 Env polyprotein,Endogenous retrovirus group K member 24 Env polyprotein,Endogenous retrovirus group K member 25 Env polyprotein,Endogenous retrovirus group K member 6 Env polyprotein,Endogenous retrovirus group K member 7 Env polyprotein,Endogenous retrovirus group K member 8 Env polyprotein,Envelope glycoprotein gp160,MECPS |
4 | D | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
5 | E, I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | F | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
7 | J | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
8 | K | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) |
Sequence modifications
H, A: 1 - 105 (PDB: 5ESZ)
H, A: 106 - 218 (UniProt: A0A087WYE1)
L, B: 1 - 108 (PDB: 5ESZ)
L, B: 109 - 214 (UniProt: P01834)
C, G: 112 - 125 (UniProt: P44815)
C, G: 126 - 197 (UniProt: Q4QX31)
C, G: 202 - 316 (UniProt: P44815)
H, A: 106 - 218 (UniProt: A0A087WYE1)
PDB | External Database | Details |
---|---|---|
Gly 219 | - | expression tag |
Leu 220 | - | expression tag |
Glu 221 | - | expression tag |
Val 222 | - | expression tag |
Leu 223 | - | expression tag |
Phe 224 | - | expression tag |
L, B: 109 - 214 (UniProt: P01834)
C, G: 112 - 125 (UniProt: P44815)
PDB | External Database | Details |
---|---|---|
Ser 111 | - | expression tag |
Leu 112 | Met 1 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 198 | - | linker |
Gly 199 | - | linker |
Ser 200 | - | linker |
Gly 201 | - | linker |
PDB | External Database | Details |
---|---|---|
- | Asp 64 | deletion |
- | Thr 65 | deletion |
- | Asp 66 | deletion |
- | Met 67 | deletion |
- | Gln 68 | deletion |
- | Tyr 69 | deletion |
Gly 317 | - | expression tag |
Leu 318 | - | expression tag |
Glu 319 | - | expression tag |
Val 320 | - | expression tag |
Leu 321 | - | expression tag |
Phe 322 | - | expression tag |
Gln 323 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 148586.7 | |
Branched | Number of molecules | 6 |
Total formula weight | 4816.4 | |
All* | Total formula weight | 153403.1 |