5ESZ
Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244
Summary for 5ESZ
Entry DOI | 10.2210/pdb5esz/pdb |
Descriptor | CH04 Heavy Chain, CH04 Light Chain, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, ... (8 entities in total) |
Functional Keywords | hiv-1, env, v1v2, ch0219, chavi, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 153403.10 |
Authors | Gorman, J.,Yang, M.,Kwong, P.D. (deposition date: 2015-11-17, release date: 2015-12-16, Last modification date: 2023-09-27) |
Primary citation | Gorman, J.,Soto, C.,Yang, M.M.,Davenport, T.M.,Guttman, M.,Bailer, R.T.,Chambers, M.,Chuang, G.Y.,DeKosky, B.J.,Doria-Rose, N.A.,Druz, A.,Ernandes, M.J.,Georgiev, I.S.,Jarosinski, M.C.,Joyce, M.G.,Lemmin, T.M.,Leung, S.,Louder, M.K.,McDaniel, J.R.,Narpala, S.,Pancera, M.,Stuckey, J.,Wu, X.,Yang, Y.,Zhang, B.,Zhou, T.,Mullikin, J.C.,Baxa, U.,Georgiou, G.,McDermott, A.B.,Bonsignori, M.,Haynes, B.F.,Moore, P.L.,Morris, L.,Lee, K.K.,Shapiro, L.,Mascola, J.R.,Kwong, P.D. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nat. Struct. Mol. Biol., 23:81-90, 2016 Cited by PubMed: 26689967DOI: 10.1038/nsmb.3144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.191 Å) |
Structure validation
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