5ESH
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73W mutant in complex with itraconazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lanosterol 14-alpha demethylase | polymer | 539 | 62014.4 | 1 | UniProt (A6ZSR0) | Saccharomyces cerevisiae (Baker's yeast) | |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one | non-polymer | 705.6 | 1 | Chemie (1YN) PubChem (3793) PubChem (21309254) PubChem (25103690) PubChem (25261097) PubChem (55283) PubChem (24867300) PubChem (56682298) PubChem (58612883) PubChem (56675666) PubChem (14179008) PubChem (14179012) PubChem (91563952) PubChem (6917738) PubChem (9961741) PubChem (122699344) PubChem (122699348) PubChem (14179009) PubChem (14179010) PubChem (14179011) PubChem (14179013) PubChem (153052543) PubChem (161302809) | |||
| 4 | D (A) | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A: 1 - 530 (UniProt: A6ZSR0)
| PDB | External Database | Details |
|---|---|---|
| Trp 73 | Gly 73 | engineered mutation |
| Gly 531 | - | expression tag |
| Gly 532 | - | expression tag |
| Arg 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 62014.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1322.1 | |
| All* | Total formula weight | 63336.5 |
