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5ESH

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73W mutant in complex with itraconazole

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0006696biological_processergosterol biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0016020cellular_componentmembrane
A0016126biological_processsterol biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0032259biological_processmethylation
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue HEM A 601
ChainResidue
APHE113
APRO379
ALEU383
AARG385
APRO462
APHE463
AGLY464
AHIS468
ACYS470
AILE471
AGLY472
ATYR126
A1YN602
AHOH743
ATYR140
ALEU147
ALYS151
AVAL311
AGLY315
ATHR318
ALEU374

site_idAC2
Number of Residues17
Detailsbinding site for residue 1YN A 602
ChainResidue
AALA69
ATYR72
ATRP73
ALEU96
ATYR126
APHE134
AILE139
APHE236
APRO238
AGLY310
AGLY314
ATHR318
ALEU380
ASER382
APHE384
AMET509
AHEM601

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG
ChainResidueDetails
APHE463-GLY472

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PDB entries from 2024-10-16

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