5ERD

Crystal structure of human Desmoglein-2 ectodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Desmoglein-2	polymer	559	62584.0	2	UniProt (Q14126) Pfam (PF00028)	Homo sapiens (Human)	Cadherin family member 5,HDGC
2	C, D, G (C, D, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
3	E (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
4	F, H, I (F, H, I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
5	DA, J, K (B, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
6	AA, BA, CA, L, M... (B, A)	alpha-D-mannopyranose	non-polymer		180.2	6	Chemie (MAN)
7	EA, FA, GA, HA, IA... (B, A)	CALCIUM ION	non-polymer		40.1	22	Chemie (CA)
8	Z (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
9	PA, QA (A, B)	water	water		18.0	192	Chemie (HOH)

Sequence modifications

A, B: 1 - 553 (UniProt: Q14126)

PDB	External Database	Details
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	125168.1
Branched	Number of molecules	7
	Total formula weight	3765.5
Non-Polymers*	Number of molecules	32
	Total formula weight	2688.3
All*	Total formula weight	131621.9

*Water molecules are not included.