5EK9
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain-containing protein 2 | polymer | 114 | 13375.4 | 2 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | C, D (A, B) | propan-2-yl ~{N}-[(2~{S},4~{R})-1-ethanoyl-6-(furan-2-yl)-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate | non-polymer | 356.4 | 2 | Chemie (5P4) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B: 344 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 342 | - | expression tag |
| Met 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26750.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 712.8 | |
| All* | Total formula weight | 27463.7 |
