5EK9
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 5P4 A 501 |
| Chain | Residue |
| A | TRP370 |
| A | PRO371 |
| A | PHE372 |
| A | LEU381 |
| A | LEU383 |
| A | CYS425 |
| A | ASN429 |
| A | HIS433 |
| A | HOH617 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 5P4 B 501 |
| Chain | Residue |
| B | TRP370 |
| B | PRO371 |
| B | LEU381 |
| B | ASN429 |
| B | ASP434 |
| B | HOH602 |
| B | HOH647 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 |
