5EFK
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (Y745F mutant) in complex with alpha tubulin K40 tripeptide substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Hdac6 protein | polymer | 364 | 40269.5 | 1 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | histone deacetylase 6 |
| 2 | B (A) | alpha tubulin K40 tripeptide | polymer | 3 | 390.4 | 1 | Danio rerio (Zebrafish) | ||
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | H (B) | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
| 8 | I (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 9 | J (A) | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 1 | Chemie (MCM) | |||
| 10 | K, L (B, A) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
B: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
| Phe 745 | Tyr 593 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40659.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 641.1 | |
| All* | Total formula weight | 41300.9 |
