5EFK
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (Y745F mutant) in complex with alpha tubulin K40 tripeptide substrate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Hdac6 protein | polymer | 364 | 40269.5 | 1 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) In PDB | Danio rerio (Zebrafish) | histone deacetylase 6 |
2 | A | alpha tubulin K40 tripeptide | polymer | 3 | 390.4 | 1 | Danio rerio (Zebrafish) | ||
3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | B | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
7 | B | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
8 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
9 | A | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 1 | Chemie (MCM) | |||
10 | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
B: 440 - 798 (UniProt: A7YT55)
PDB | External Database | Details |
---|---|---|
Ser 435 | - | expression tag |
Asn 436 | - | expression tag |
Ala 437 | - | expression tag |
Gly 438 | - | expression tag |
Gly 439 | - | expression tag |
Phe 745 | Tyr 593 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 40659.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 641.1 | |
All* | Total formula weight | 41300.9 |