5EFH
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, A) | Hdac6 protein | polymer | 364 | 40285.5 | 2 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | histone deacetylase 6 |
| 2 | C, J (D, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, K, L (D, A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | F, M (D, A) | 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol | non-polymer | 258.3 | 2 | Chemie (FKS) | |||
| 5 | G, H, I, N, O... (D, A) | BROMIDE ION | non-polymer | 79.9 | 7 | Chemie (BR) | |||
| 6 | R (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | S (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | T, U (D, A) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
D, A: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80571.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1517.3 | |
| All* | Total formula weight | 82088.2 |
