5EFH

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0004407	molecular_function	histone deacetylase activity
A	0006325	biological_process	chromatin organization
A	0016575	biological_process	histone deacetylation
D	0000118	cellular_component	histone deacetylase complex
D	0004407	molecular_function	histone deacetylase activity
D	0006325	biological_process	chromatin organization
D	0016575	biological_process	histone deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN D 2001

Chain	Residue
D	ASP612
D	HIS614
D	ASP705
D	FKS2004

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site_id	AC2
Number of Residues	5
Details	binding site for residue K D 2002

Chain	Residue
D	ASP610
D	ASP612
D	HIS614
D	SER633
D	LEU634

---

site_id	AC3
Number of Residues	6
Details	binding site for residue K D 2003

Chain	Residue
D	PHE623
D	ASP626
D	VAL629
D	TYR662
D	HOH2118
D	HOH2181

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site_id	AC4
Number of Residues	16
Details	binding site for residue FKS D 2004

Chain	Residue
D	PRO571
D	HIS573
D	HIS574
D	GLY582
D	PHE583
D	CYS584
D	ASP612
D	HIS614
D	ASP705
D	GLU742
D	GLY743
D	TYR745
D	ZN2001
D	BR2005
D	BR2007
D	HOH2145

---

site_id	AC5
Number of Residues	2
Details	binding site for residue BR D 2005

Chain	Residue
D	HIS614
D	FKS2004

---

site_id	AC6
Number of Residues	3
Details	binding site for residue BR D 2006

Chain	Residue
D	ARG481
D	LEU483
D	SER484

---

site_id	AC7
Number of Residues	1
Details	binding site for residue BR D 2007

Chain	Residue
D	FKS2004

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN A 2001

Chain	Residue
A	ASP612
A	HIS614
A	ASP705
A	FKS2004

---

site_id	AC9
Number of Residues	5
Details	binding site for residue K A 2002

Chain	Residue
A	ASP610
A	ASP612
A	HIS614
A	SER633
A	LEU634

---

site_id	AD1
Number of Residues	6
Details	binding site for residue K A 2003

Chain	Residue
A	PHE623
A	ASP626
A	VAL629
A	TYR662
A	HOH2104
A	HOH2185

---

site_id	AD2
Number of Residues	17
Details	binding site for residue FKS A 2004

Chain	Residue
A	SER531
A	PRO571
A	HIS573
A	HIS574
A	GLY582
A	PHE583
A	CYS584
A	ASP612
A	HIS614
A	PHE643
A	ASP705
A	GLU742
A	GLY743
A	TYR745
A	ZN2001
A	BR2005
A	BR2006

---

site_id	AD3
Number of Residues	2
Details	binding site for residue BR A 2005

Chain	Residue
A	HIS614
A	FKS2004

---

site_id	AD4
Number of Residues	1
Details	binding site for residue BR A 2006

Chain	Residue
A	FKS2004

---

site_id	AD5
Number of Residues	1
Details	binding site for residue BR A 2007

Chain	Residue
A	HOH2189

---

site_id	AD6
Number of Residues	1
Details	binding site for residue BR A 2008

Chain	Residue
A	HOH2178

---

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO A 2009

Chain	Residue
A	ASP449
A	ARG451

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site_id	AD8
Number of Residues	6
Details	binding site for residue GOL A 2010

Chain	Residue
A	GLU576
A	ASN617
A	HIS621
A	SER646
A	ASP648
A	HOH2141

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