5EE7
Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucagon receptor,Endolysin,Glucagon receptor | polymer | 452 | 51279.5 | 1 | UniProt (P47871) UniProt (P00720) Pfam (PF00002) Pfam (PF00959) | Homo sapiens (Human) | GL-R,Lysis protein,Lysozyme,Muramidase,GL-R |
| 2 | B (A) | 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid | non-polymer | 588.5 | 1 | Chemie (5MV) | |||
| 3 | C, D, E, F, G... (A) | OLEIC ACID | non-polymer | 282.5 | 14 | Chemie (OLA) | |||
| 4 | Q (A) | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL | non-polymer | 398.5 | 1 | Chemie (PE5) | |||
| 5 | R (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 6 | S (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 136 - 254 (UniProt: P47871)
A: 255 - 1158 (UniProt: P00720)
A: 259 - 417 (UniProt: P47871)
| PDB | External Database | Details |
|---|---|---|
| Gly 137 | Met 137 | engineered mutation |
| Ala 154 | Gly 154 | engineered mutation |
| Ala 173 | Arg 173 | engineered mutation |
| Leu 182 | Ala 182 | engineered mutation |
| Ala 190 | Ser 190 | engineered mutation |
| Phe 193 | Val 193 | engineered mutation |
| Glu 207 | Gly 207 | engineered mutation |
| Ala 223 | Gly 223 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 255 | Met 1 | linker |
| Gly 1010 | Arg 12 | engineered mutation |
| Thr 1052 | Cys 54 | engineered mutation |
| Ala 1095 | Cys 97 | engineered mutation |
| Arg 1135 | Ile 137 | engineered mutation |
| Tyr 1159 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 276 | Met 276 | engineered mutation |
| Ala 344 | Lys 344 | engineered mutation |
| Phe 362 | Glu 362 | engineered mutation |
| Ala 387 | Phe 387 | engineered mutation |
| Ala 418 | - | expression tag |
| Ala 419 | - | expression tag |
| Ala 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
| His 428 | - | expression tag |
| His 429 | - | expression tag |
| His 430 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51279.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 5091.5 | |
| All* | Total formula weight | 56371.0 |
