5EDE
human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, D | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 316 | 36600.2 | 3 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
2 | B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 315 | 36472.1 | 1 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | A, B, C, D | 1-(4-chlorophenyl)-3-methyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]thieno[2,3-c]pyrazole-5-carboxamide | non-polymer | 375.9 | 4 | Chemie (5M6) | |||
7 | water | water | 18.0 | 780 | Chemie (HOH) |
Sequence modifications
A, C, D: 457 - 770 (UniProt: Q9Y233)
B: 458 - 770 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Ala 456 | - | expression tag |
Arg 470 | Lys 460 | conflict |
Ala 771 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 457 | - | expression tag |
Arg 470 | Lys 460 | conflict |
Ala 771 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 146272.7 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 2046.5 | |
All* | Total formula weight | 148319.3 |