5EDE
human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
C | 0007165 | biological_process | signal transduction |
C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
D | 0007165 | biological_process | signal transduction |
D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue ZN A 801 |
Chain | Residue |
A | HIS529 |
A | HIS563 |
A | ASP564 |
A | ASP674 |
A | HOH970 |
A | HOH1016 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 802 |
Chain | Residue |
A | HOH975 |
A | HOH978 |
A | HOH1048 |
A | ASP564 |
A | HOH931 |
A | HOH970 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue GOL A 803 |
Chain | Residue |
A | PRO481 |
A | PHE482 |
A | GLU483 |
A | ASN484 |
B | ARG520 |
B | ARG568 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue 5M6 A 804 |
Chain | Residue |
A | LEU675 |
A | SER677 |
A | VAL678 |
A | MET713 |
A | MET714 |
A | GLN726 |
A | PHE729 |
A | HOH981 |
A | HOH1026 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue ZN B 801 |
Chain | Residue |
B | HIS529 |
B | HIS563 |
B | ASP564 |
B | ASP674 |
B | HOH919 |
B | HOH1010 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG B 802 |
Chain | Residue |
B | ASP564 |
B | HOH919 |
B | HOH924 |
B | HOH972 |
B | HOH977 |
B | HOH1040 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue GOL B 803 |
Chain | Residue |
B | PRO481 |
B | GLU483 |
B | ASN484 |
C | ARG520 |
C | ARG568 |
C | PHE570 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue 5M6 B 804 |
Chain | Residue |
B | SER573 |
B | LEU675 |
B | SER677 |
B | VAL678 |
B | ILE692 |
B | MET713 |
B | MET714 |
B | GLN726 |
B | PHE729 |
B | HOH923 |
B | HOH954 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue ZN C 801 |
Chain | Residue |
C | HIS529 |
C | HIS563 |
C | ASP564 |
C | ASP674 |
C | HOH950 |
C | HOH963 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue MG C 802 |
Chain | Residue |
C | ASP564 |
C | HOH935 |
C | HOH946 |
C | HOH950 |
C | HOH956 |
C | HOH1036 |
site_id | AD2 |
Number of Residues | 11 |
Details | binding site for residue 5M6 C 803 |
Chain | Residue |
C | TYR524 |
C | SER573 |
C | LEU635 |
C | LEU675 |
C | SER677 |
C | VAL678 |
C | ILE692 |
C | MET713 |
C | GLN726 |
C | PHE729 |
C | HOH962 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue ZN D 801 |
Chain | Residue |
D | HIS529 |
D | HIS563 |
D | ASP564 |
D | ASP674 |
D | HOH939 |
D | HOH955 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue MG D 802 |
Chain | Residue |
D | ASP564 |
D | HOH905 |
D | HOH934 |
D | HOH939 |
D | HOH988 |
D | HOH993 |
site_id | AD5 |
Number of Residues | 10 |
Details | binding site for residue 5M6 D 803 |
Chain | Residue |
D | PHE729 |
D | HOH902 |
D | SER573 |
D | LEU635 |
D | LEU675 |
D | SER677 |
D | VAL678 |
D | ILE692 |
D | MET713 |
D | GLN726 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
Chain | Residue | Details |
A | HIS563-TYR574 | |
B | HIS563-TYR574 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF |
Chain | Residue | Details |
B | ASN572 | |
D | SER616 | |
D | GLN650 | |
D | MET669 | |
B | SER616 | |
B | GLN650 | |
B | MET669 | |
C | ASN572 | |
C | SER616 | |
C | GLN650 | |
C | MET669 | |
D | ASN572 |