5ED2

Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Double-stranded RNA-specific editase 1	polymer	403	45004.4	2	UniProt (P78563) Pfam (PF02137)	Homo sapiens (human)	adenosine deaminase acting on RNA
2	B, E (B, E)	RNA (5'-R(P*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3')	polymer	23	7415.4	2		Homo sapiens
3	C, F (C, F)	RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3')	polymer	23	7335.5	2		Homo sapiens
4	G, I (A, D)	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	2	Chemie (IHP)
5	H, J (A, D)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, D: 299 - 701 (UniProt: P78563)

PDB	External Database	Details
Gln 488	Glu 516	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	119510.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1450.9
All*	Total formula weight	120961.5

*Water molecules are not included.