5ED1
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from S. cerevisiae BDF2 gene
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Double-stranded RNA-specific editase 1 | polymer | 403 | 45004.4 | 2 | UniProt (P78563) Pfam (PF02137) | Homo sapiens (human) | adenosine deaminase acting on RNA |
| 2 | B (B) | RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') | polymer | 23 | 7225.3 | 1 | Saccharomyces cerevisiae | ||
| 3 | C (C) | RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') | polymer | 23 | 7489.6 | 1 | Saccharomyces cerevisiae | ||
| 4 | E, G (A, D) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 5 | F, H (A, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I, J, K (A, B, D) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, D: 299 - 701 (UniProt: P78563)
| PDB | External Database | Details |
|---|---|---|
| Gln 488 | Glu 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 104723.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1450.9 | |
| All* | Total formula weight | 106174.5 |
