5EA1
Crystal Structure of SMARCA4 bromodomain in complex with MPD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Transcription activator BRG1 | polymer | 132 | 15494.6 | 3 | UniProt (P51532) Pfam (PF00439) | Homo sapiens (Human) | ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
| 2 | D, F, H (A, B, C) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 3 | Chemie (MRD) | |||
| 3 | E, G, I (A, B, C) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 3 | Chemie (MPD) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B, C: 1451 - 1580 (UniProt: P51532)
| PDB | External Database | Details |
|---|---|---|
| Ser 1449 | - | expression tag |
| Met 1450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 46483.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 709.0 | |
| All* | Total formula weight | 47192.7 |
