5EA1
Crystal Structure of SMARCA4 bromodomain in complex with MPD
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MRD A 1601 |
| Chain | Residue |
| A | PHE1485 |
| A | PRO1489 |
| A | TYR1497 |
| A | PHE1539 |
| A | ASN1540 |
| A | MPD1602 |
| A | HOH1701 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MPD A 1602 |
| Chain | Residue |
| A | PHE1539 |
| A | ASN1540 |
| A | MRD1601 |
| A | HOH1701 |
| A | PHE1485 |
| A | PRO1489 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MRD B 1601 |
| Chain | Residue |
| B | VAL1484 |
| B | PHE1485 |
| B | TYR1497 |
| B | ALA1536 |
| B | ASN1540 |
| B | MPD1602 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MPD B 1602 |
| Chain | Residue |
| B | VAL1484 |
| B | PHE1485 |
| B | TYR1497 |
| B | ALA1536 |
| B | ASN1540 |
| B | MRD1601 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue MRD C 1601 |
| Chain | Residue |
| B | GLU1548 |
| C | PRO1489 |
| C | PHE1539 |
| C | ASN1540 |
| C | MPD1602 |
| C | HOH1704 |
| C | HOH1716 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MPD C 1602 |
| Chain | Residue |
| B | GLU1548 |
| C | PRO1489 |
| C | PHE1539 |
| C | ASN1540 |
| C | MRD1601 |
| C | HOH1704 |
| C | HOH1716 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslndlekdvml.LcqNAqtF |
| Chain | Residue | Details |
| A | SER1482-PHE1539 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 333 |
| Details | Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Required for binding to 'Lys-15'-acetylated histone 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
