5E8X
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) IN COMPLEX WITH STAUROSPORINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TGF-beta receptor type-1 | polymer | 307 | 35226.6 | 1 | UniProt (P36897) Pfam (PF00069) | Homo sapiens (Human) | TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TbetaR-I |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (44259) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (25322871) PubChem (28684983) PubChem (451705) PubChem (44120114) PubChem (44537813) PubChem (49831000) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (5459111) PubChem (73953205) PubChem (6419748) PubChem (86306248) PubChem (358479) PubChem (9804568) PubChem (9937179) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (122130844) PubChem (12046017) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | D (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 200 - 503 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Gly 197 | - | expression tag |
| His 198 | - | expression tag |
| Met 199 | - | expression tag |
| Asp 204 | Thr 204 | engineered mutation |
| Val 211 | Ile 211 | engineered mutation |
| Phe 249 | Tyr 249 | engineered mutation |
| Thr 280 | Ser 280 | engineered mutation |
| Phe 282 | Tyr 282 | engineered mutation |
| Asn 287 | Ser 287 | engineered mutation |
| Cys 350 | Ala 350 | engineered mutation |
| Phe 352 | Leu 352 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35226.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 558.6 | |
| All* | Total formula weight | 35785.2 |
