5E8X
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) IN COMPLEX WITH STAUROSPORINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue STU A 601 |
| Chain | Residue |
| A | VAL211 |
| A | ASP281 |
| A | PHE282 |
| A | HIS283 |
| A | GLY286 |
| A | ASN287 |
| A | LYS337 |
| A | LEU340 |
| A | CYS350 |
| A | ASP351 |
| A | GLY212 |
| A | LYS213 |
| A | GLY214 |
| A | VAL219 |
| A | ALA230 |
| A | LYS232 |
| A | LEU260 |
| A | THR280 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | HIS285 |
| A | TYR291 |
| A | TYR295 |
| A | HOH714 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRFGEVWrGkwrgee............VAVK |
| Chain | Residue | Details |
| A | VAL211-LYS232 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE329-VAL341 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP333 | |
| Chain | Residue | Details |
| A | VAL211 | |
| A | LYS232 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33914044 |
| Chain | Residue | Details |
| A | LYS268 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS391 | |
