5E8M
Crystal structure of human heparanase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heparanase | polymer | 389 | 43733.3 | 1 | UniProt (Q9Y251) Pfam (PF03662) | Homo sapiens (Human) | Endo-glucoronidase,Heparanase-1,Hpa1, glycoside hydrolase |
| 2 | B (B) | Heparanase | polymer | 77 | 8542.8 | 1 | UniProt (Q9Y251) | Homo sapiens (Human) | Endo-glucoronidase,Heparanase-1,Hpa1, glycoside hydrolase |
| 3 | C (C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 4 | D, E, F, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | H, I, J, K, L... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 6 | V, W, X (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | AA, Z (B, A) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A: 158 - 543 (UniProt: Q9Y251)
B: 1 - 74 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Asp 155 | - | expression tag |
| Pro 156 | - | expression tag |
| Gly 157 | - | expression tag |
| Arg 307 | Lys 307 | variant |
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52276.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 1922.2 | |
| All* | Total formula weight | 54565.7 |
