5E2B

Crystal structure of NTMT1 in complex with N-terminally methylated PPKRIA peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	N-terminal Xaa-Pro-Lys N-methyltransferase 1	polymer	241	27320.1	2	UniProt (Q9BV86) Pfam (PF05891)	Homo sapiens (Human)	Alpha N-terminal protein methyltransferase 1A,Methyltransferase-like protein 11A,N-terminal RCC1 methyltransferase,X-Pro-Lys N-terminal protein methyltransferase 1A,NTM1A
2	C, D (D, E)	RCC1	polymer	6	696.9	2	UniProt (by SIFTS) (P18754)	Homo sapiens
3	E, HA (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	F, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	AA, AB, BA, BB, CA... (A, B, D, E)	UNKNOWN ATOM OR ION	non-polymer			50	Chemie (UNX)
6	GB, HB, IB, JB (A, B, D, E)	water	water		18.0	385	Chemie (HOH)

Sequence modifications

A, B: 2 - 223 (UniProt: Q9BV86)

PDB	External Database	Details
Met -17	-	initiating methionine
Gly -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
Gly -5	-	expression tag
Leu -4	-	expression tag
Val -3	-	expression tag
Pro -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	56033.9
Non-Polymers*	Number of molecules	54
	Total formula weight	953.0
All*	Total formula weight	56986.9

*Water molecules are not included.