5E2B

Crystal structure of NTMT1 in complex with N-terminally methylated PPKRIA peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006480	biological_process	N-terminal protein amino acid methylation
A	0007051	biological_process	spindle organization
A	0007059	biological_process	chromosome segregation
A	0008168	molecular_function	methyltransferase activity
A	0008276	molecular_function	protein methyltransferase activity
A	0018013	biological_process	N-terminal peptidyl-glycine methylation
A	0018016	biological_process	N-terminal peptidyl-proline dimethylation
A	0032259	biological_process	methylation
A	0035572	biological_process	N-terminal peptidyl-serine dimethylation
A	0035573	biological_process	N-terminal peptidyl-serine trimethylation
A	0042054	molecular_function	histone methyltransferase activity
A	0071885	molecular_function	N-terminal protein N-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006480	biological_process	N-terminal protein amino acid methylation
B	0007051	biological_process	spindle organization
B	0007059	biological_process	chromosome segregation
B	0008168	molecular_function	methyltransferase activity
B	0008276	molecular_function	protein methyltransferase activity
B	0018013	biological_process	N-terminal peptidyl-glycine methylation
B	0018016	biological_process	N-terminal peptidyl-proline dimethylation
B	0032259	biological_process	methylation
B	0035572	biological_process	N-terminal peptidyl-serine dimethylation
B	0035573	biological_process	N-terminal peptidyl-serine trimethylation
B	0042054	molecular_function	histone methyltransferase activity
B	0071885	molecular_function	N-terminal protein N-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue SAH A 301

Chain	Residue
A	TRP20
A	PHE96
A	GLY118
A	LEU119
A	GLN120
A	GLN135
A	TRP136
A	VAL137
A	HIS140
A	HOH424
A	HOH467
A	MET30
A	HOH538
D	3BY1
A	GLY69
A	GLY71
A	ARG74
A	ILE75
A	ASP91
A	ILE92
A	THR93

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
A	HIS36
A	ILE37
A	HOH411
A	HOH489
B	TYR19
B	GLY32
B	HOH463

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site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 303

Chain	Residue
A	GLU86
A	ARG112
A	HOH436
A	HOH501
B	ARG46

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site_id	AC4
Number of Residues	21
Details	binding site for residue SAH B 301

Chain	Residue
B	TRP20
B	MET30
B	GLY69
B	GLY71
B	ARG74
B	ILE75
B	ASP91
B	ILE92
B	THR93
B	PHE96
B	GLY118
B	LEU119
B	GLN120
B	GLN135
B	TRP136
B	VAL137
B	HIS140
B	HOH437
B	HOH473
B	HOH493
E	3BY1

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:26543159, ECO:0000269|PubMed:26543161, ECO:0007744|PDB:2EX4, ECO:0007744|PDB:5CVD, ECO:0007744|PDB:5CVE, ECO:0007744|PDB:5E1D, ECO:0007744|PDB:5E1M, ECO:0007744|PDB:5E1O, ECO:0007744|PDB:5E2A, ECO:0007744|PDB:5E2B

Chain	Residue	Details
A	GLN135
B	GLY69
B	ARG74
B	ASP91
B	LEU119
B	GLN135
A	GLY69
A	ARG74
A	ASP91
A	LEU119

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	THR2
B	THR2

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