5E0H
1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (18-mer) inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Norovirus 3C-like protease | polymer | 188 | 20126.1 | 2 | UniProt (Q83883) | Norwalk virus (Hu/NV/NV/1968/US) | |
| 2 | C (A) | (phenylmethyl) ~{N}-[(9~{S},12~{S},15~{S})-9-(hydroxymethyl)-12-(2-methylpropyl)-6,11,14-tris(oxidanylidene)-1,5,10,13,18,19-hexazabicyclo[15.2.1]icosa-17(20),18-dien-15-yl]carbamate | non-polymer | 557.6 | 1 | BIRD (PRD_002202) Chemie (5LH) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 181 (UniProt: Q83883)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40252.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 649.7 | |
| All* | Total formula weight | 40902.0 |
