5E0H
1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (18-mer) inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 5LH A 201 |
| Chain | Residue |
| A | HIS30 |
| A | ALA159 |
| A | ALA160 |
| A | HOH307 |
| B | ARG100 |
| A | ILE109 |
| A | GLN110 |
| A | THR134 |
| A | ILE135 |
| A | PRO136 |
| A | CYS139 |
| A | HIS157 |
| A | ALA158 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| A | TRP6 |
| A | SER7 |
| A | LYS88 |
| B | TRP6 |
| B | SER7 |
| B | LYS88 |
| B | HOH305 |
| B | HOH308 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
