5DW1
X-ray crystal structure of human BRD2(BD2) in complex with RVX297 to 1.55 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bromodomain-containing protein 2 | polymer | 113 | 13318.4 | 4 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1, Really interesting new gene 3 protein |
| 2 | E, F, G, I (A, B, C, D) | 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one | non-polymer | 423.5 | 4 | Chemie (5GD) | |||
| 3 | H, J (C, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 583 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 345 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 343 | - | expression tag |
| Met 344 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 53273.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1740.0 | |
| All* | Total formula weight | 55013.4 |
