5DLW
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | polymer | 827 | 95003.6 | 1 | UniProt (Q64610) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) | Rattus norvegicus (Norway Rat) | E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD |
| 2 | B (B) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G91845HM) | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | F (A) | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate | non-polymer | 436.5 | 1 | Chemie (NKP) | |||
| 6 | G (A) | 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid | non-polymer | 499.7 | 1 | Chemie (5D5) | |||
| 7 | H, I (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 8 | J, K, L, M, N... (A) | IODIDE ION | non-polymer | 126.9 | 13 | Chemie (IOD) | |||
| 9 | W, X (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
| 10 | Y, Z (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 11 | AA (A) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A: 36 - 862 (UniProt: Q64610)
| PDB | External Database | Details |
|---|---|---|
| Ala 410 | Asn 410 | engineered mutation |
| Thr 591 | Arg 591 | cloning artifact |
| Ala 806 | Asn 806 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 95003.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1235.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3103.2 | |
| All* | Total formula weight | 99341.9 |
