5DLW
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001953 | biological_process | negative regulation of cell-matrix adhesion |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004528 | molecular_function | phosphodiesterase I activity |
| A | 0004622 | molecular_function | lysophospholipase activity |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006955 | biological_process | immune response |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0010634 | biological_process | positive regulation of epithelial cell migration |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0030149 | biological_process | sphingolipid catabolic process |
| A | 0030247 | molecular_function | polysaccharide binding |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0034638 | biological_process | phosphatidylcholine catabolic process |
| A | 0044849 | biological_process | estrous cycle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| A | 0050731 | biological_process | positive regulation of peptidyl-tyrosine phosphorylation |
| A | 0051894 | biological_process | positive regulation of focal adhesion assembly |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0071276 | biological_process | cellular response to cadmium ion |
| A | 0071392 | biological_process | cellular response to estradiol stimulus |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| A | 1903165 | biological_process | response to polycyclic arene |
| A | 2000394 | biological_process | positive regulation of lamellipodium morphogenesis |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC |
| Chain | Residue | Details |
| A | CYS73-CYS93 | |
| A | CYS117-CYS137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:12633853, ECO:0000269|PubMed:27268273 |
| Chain | Residue | Details |
| A | THR209 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:27075612, ECO:0000269|PubMed:27268273, ECO:0000269|PubMed:27660691, ECO:0007744|PDB:2XR9, ECO:0007744|PDB:2XRG, ECO:0007744|PDB:5DLT, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5DLW, ECO:0007744|PDB:5IJQ, ECO:0007744|PDB:5IJS, ECO:0007744|PDB:5L0B, ECO:0007744|PDB:5L0E, ECO:0007744|PDB:5L0K, ECO:0007744|PDB:5LQQ |
| Chain | Residue | Details |
| A | ASP311 | |
| A | HIS315 | |
| A | HIS359 | |
| A | HIS474 | |
| A | ASP171 | |
| A | THR209 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R1E6 |
| Chain | Residue | Details |
| A | LEU243 | |
| A | PHE210 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27075612, ECO:0007744|PDB:5DLW |
| Chain | Residue | Details |
| A | ASN230 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27075612, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5DLW |
| Chain | Residue | Details |
| A | TYR306 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:27075612, ECO:0000269|PubMed:27268273, ECO:0000269|PubMed:27660691, ECO:0007744|PDB:2XRG, ECO:0007744|PDB:5DLT, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5IJS, ECO:0007744|PDB:5L0B, ECO:0007744|PDB:5L0E, ECO:0007744|PDB:5L0K, ECO:0007744|PDB:5LQQ |
| Chain | Residue | Details |
| A | ASP358 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:27075612, ECO:0000269|PubMed:27268273, ECO:0007744|PDB:2XR9, ECO:0007744|PDB:2XRG, ECO:0007744|PDB:5DLT, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5DLW, ECO:0007744|PDB:5IJQ, ECO:0007744|PDB:5L0K, ECO:0007744|PDB:5LQQ |
| Chain | Residue | Details |
| A | PRO764 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:27075612, ECO:0000269|PubMed:27268273, ECO:0007744|PDB:2XR9, ECO:0007744|PDB:2XRG, ECO:0007744|PDB:5DLT, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5DLW, ECO:0007744|PDB:5IJQ, ECO:0007744|PDB:5IJS, ECO:0007744|PDB:5L0K, ECO:0007744|PDB:5LQQ |
| Chain | Residue | Details |
| A | THR772 | |
| A | HIS766 | |
| A | TYR768 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:27075612, ECO:0000269|PubMed:27268273, ECO:0007744|PDB:2XR9, ECO:0007744|PDB:2XRG, ECO:0007744|PDB:5DLT, ECO:0007744|PDB:5DLV, ECO:0007744|PDB:5DLW, ECO:0007744|PDB:5IJQ, ECO:0007744|PDB:5IJS, ECO:0007744|PDB:5L0K |
| Chain | Residue | Details |
| A | ILE770 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN398 | |
| A | ALA410 | |
| A | ASP610 | |
| A | HIS831 | |
| A | ASN53 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21240271 |
| Chain | Residue | Details |
| A | ASN524 |
