5DLQ
Crystal structure of RanGTP-Exportin 4-eIF5A complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, A) | Exportin-4 | polymer | 1113 | 125894.0 | 2 | UniProt (Q9ESJ0) Pfam (PF08767) | Mus musculus (Mouse) | Exp4 |
| 2 | B, E (C, D) | GTP-binding nuclear protein Ran | polymer | 176 | 20192.5 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 3 | C, F (F, E) | Eukaryotic translation initiation factor 5A-1 | polymer | 141 | 15588.0 | 2 | UniProt (P63241) Pfam (PF21485) Pfam (PF01287) | Homo sapiens (Human) | eIF-5A1,Eukaryotic initiation factor 5A isoform 1,eIF-5A,Rev-binding factor,eIF-4D |
| 4 | G, I (C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 5 | H, J (C, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
B, A: 1 - 1151 (UniProt: Q9ESJ0)
C, D: 5 - 180 (UniProt: P62826)
F, E: 15 - 154 (UniProt: P63241)
| PDB | External Database | Details |
|---|---|---|
| - | Pro 241 | deletion |
| - | Lys 242 | deletion |
| - | Leu 243 | deletion |
| - | Gly 244 | deletion |
| - | Arg 245 | deletion |
| - | His 246 | deletion |
| - | Tyr 247 | deletion |
| - | Ile 248 | deletion |
| - | Ala 249 | deletion |
| - | Met 250 | deletion |
| - | Phe 251 | deletion |
| - | Glu 252 | deletion |
| - | Ser 253 | deletion |
| - | Ser 254 | deletion |
| - | Gln 255 | deletion |
| - | Asn 256 | deletion |
| - | Val 257 | deletion |
| - | Leu 258 | deletion |
| - | Leu 259 | deletion |
| - | Lys 260 | deletion |
| - | Ser 930 | deletion |
| - | Asp 931 | deletion |
| - | Thr 932 | deletion |
| - | Asp 933 | deletion |
| - | Glu 934 | deletion |
| - | Val 935 | deletion |
| - | Phe 936 | deletion |
| - | Arg 937 | deletion |
| - | Gly 938 | deletion |
| - | His 939 | deletion |
| - | Glu 940 | deletion |
| - | Pro 941 | deletion |
| - | Gly 942 | deletion |
| - | Gln 943 | deletion |
| - | Ala 944 | deletion |
| - | Ala 945 | deletion |
| - | Gly 946 | deletion |
| - | Arg 947 | deletion |
| Tyr 1085 | His 1085 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 323349.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1095.0 | |
| All* | Total formula weight | 324444.0 |
