5DLQ
Crystal structure of RanGTP-Exportin 4-eIF5A complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, A) | Exportin-4 | polymer | 1113 | 125894.0 | 2 | UniProt (Q9ESJ0) Pfam (PF08767) | Mus musculus (Mouse) | Exp4 |
| 2 | B, E (C, D) | GTP-binding nuclear protein Ran | polymer | 176 | 20192.5 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 3 | C, F (F, E) | Eukaryotic translation initiation factor 5A-1 | polymer | 141 | 15588.0 | 2 | UniProt (P63241) Pfam (PF21485) Pfam (PF01287) | Homo sapiens (Human) | eIF-5A1,Eukaryotic initiation factor 5A isoform 1,eIF-5A,Rev-binding factor,eIF-4D |
| 4 | G, I (C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | H, J (C, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) |
Sequence modifications
B, A: 1 - 1151 (UniProt: Q9ESJ0)
C, D: 5 - 180 (UniProt: P62826)
F, E: 15 - 154 (UniProt: P63241)
| PDB | External Database | Details |
|---|---|---|
| - | Pro 241 | deletion |
| - | Lys 242 | deletion |
| - | Leu 243 | deletion |
| - | Gly 244 | deletion |
| - | Arg 245 | deletion |
| - | His 246 | deletion |
| - | Tyr 247 | deletion |
| - | Ile 248 | deletion |
| - | Ala 249 | deletion |
| - | Met 250 | deletion |
| - | Phe 251 | deletion |
| - | Glu 252 | deletion |
| - | Ser 253 | deletion |
| - | Ser 254 | deletion |
| - | Gln 255 | deletion |
| - | Asn 256 | deletion |
| - | Val 257 | deletion |
| - | Leu 258 | deletion |
| - | Leu 259 | deletion |
| - | Lys 260 | deletion |
| - | Ser 930 | deletion |
| - | Asp 931 | deletion |
| - | Thr 932 | deletion |
| - | Asp 933 | deletion |
| - | Glu 934 | deletion |
| - | Val 935 | deletion |
| - | Phe 936 | deletion |
| - | Arg 937 | deletion |
| - | Gly 938 | deletion |
| - | His 939 | deletion |
| - | Glu 940 | deletion |
| - | Pro 941 | deletion |
| - | Gly 942 | deletion |
| - | Gln 943 | deletion |
| - | Ala 944 | deletion |
| - | Ala 945 | deletion |
| - | Gly 946 | deletion |
| - | Arg 947 | deletion |
| Tyr 1085 | His 1085 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 323349.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1095.0 | |
| All* | Total formula weight | 324444.0 |
