5DJC
Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Ig gamma-1 chain C region | polymer | 227 | 25506.9 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B, E (B, E) | Ig gamma-1 chain C region | polymer | 240 | 26998.3 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C, F (C, F) | Fc-III peptide | polymer | 13 | 1533.7 | 2 | synthetic construct | ||
| 4 | G, H, I, J (G, H, I, J) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1422.3 | 4 | In PDB GlyTouCan (G61334IA) | |||
| 5 | K (D) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 6 | L, M, N, O, P (A, B, C, D, E) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A, D: 221 - 447 (UniProt: P01857)
B, E: 221 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Glu 356 | Asp 239 | variant |
| Met 358 | Leu 241 | variant |
| Val 368 | Leu 251 | engineered mutation |
| Ala 407 | Tyr 290 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| His 208 | - | expression tag |
| His 209 | - | expression tag |
| His 210 | - | expression tag |
| His 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| His 215 | - | expression tag |
| Ser 216 | - | expression tag |
| Gly 217 | - | expression tag |
| Ser 218 | - | expression tag |
| Gly 219 | - | expression tag |
| Ser 220 | - | expression tag |
| Glu 252 | Met 135 | engineered mutation |
| Ala 253 | Ile 136 | engineered mutation |
| Glu 356 | Asp 239 | variant |
| Met 358 | Leu 241 | variant |
| Val 366 | Thr 249 | engineered mutation |
| Phe 409 | Lys 292 | engineered mutation |
| Ala 435 | His 318 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 108077.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 5689.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 126.9 | |
| All* | Total formula weight | 113894.0 |
