5D7P
Crystal structure of human Sirt2 in complex with ADPR and EX-243
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 304 | 34416.7 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (Human) | Sirtuin 2, Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | C, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, H (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 4 | E, F, I, J (A, B) | (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide | non-polymer | 248.7 | 4 | Chemie (OCZ) | |||
| 5 | K (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence modifications
A, B: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 53 | - | expression tag |
| His 54 | - | expression tag |
| Met 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68833.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2350.4 | |
| All* | Total formula weight | 71183.9 |
